The safest maximum daily dose of Tylenol 500 mg for adults is 6 tablets (3000 mg). During acute overdoses, barbiturates can enhance the formation of toxic acetaminophen metabolites. Tear or cut open the powder packet and pour the powder directly on the tongue. Also, chronic alcohol use can deplete liver glutathione stores. pregelatinized starch, microcrystalline cellulose, povidone (PVP K-30), colloidal silicon dioxide, croscarmellose sodium, stearic acid. The federal Omnibus Budget Reconciliation Act (OBRA) regulates medication use in residents (e.g., geriatric adults) of long-term care facilities (LTCFs). . You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Patients who have experienced a serious skin reaction with acetaminophen should not take the drug again; discuss alternative pain relievers/fever reducers with these patients and/or their caregivers. During acute overdoses, barbiturates can enhance the formation of toxic acetaminophen metabolites. As a single 125 mg or 40 mg oral dose, the inhibitory effect of aprepitant on CYP3A4 is weak, with the AUC of midazolam increased by 1.5-fold and 1.2-fold, respectively. 15 mg/kg/dose IV every 6 hours as needed. 6 C. 7 D. 10 - B. Max daily dose: 75 mg/kg/day. NOTE: Acetaminophen-induced hepatotoxicity often involves the use of more than 1 acetaminophen-containing product. During acute overdoses, barbiturates can enhance the formation of toxic acetaminophen metabolites. Ensure dosing intervals and maximum daily dosage limits are based on all routes of administration (e.g., intravenous, oral, rectal) and all products containing acetaminophen, including both single-entity and combination products. SingleCare Services LLC ('SingleCare') is the vendor of the prescription discount plan, including their. Douleur Soulagement Mapap 500 MG Force Actaminophne Glule $15.60 Buy It Now , $7.46 Shipping , 60-Day Returns, eBay Money Back Guarantee Seller: herbsproonline (50,379) 97.7% , Location: Hayward, California, US , Ships to: WORLDWIDE, Item: 204172561600 Large observational studies of newborns exposed to oral acetaminophen during the first trimester have not shown an increased risk for congenital malformations or major birth defects; however, these studies cannot definitely establish the absence of risk because of methodological limitations. Omeprazole; Sodium Bicarbonate: (Minor) Antacids can delay the oral absorption of acetaminophen, but the interactions are not likely to be clinically significant as the extent of acetaminophen absorption is not appreciably affected. (Moderate) Concomitant use of acetaminophen with rifampin may increase the known risk of hepatotoxicity in relation to each drug. 20 mg/kg/dose PR every 6 to 8 hours as needed. Efficacy of IV acetaminophen for the treatment of acute pain has not been established in neonates, infants, and children younger than 2 years. Acetaminophen inhibits both isoforms of central cyclooxygenase, COX-1 and COX-2. During a study among 12 healthy volunteers, concomitant administration of acetaminophen 4 g/day with lamotrigine at steady-state increased the formation clearance of lamotrigine glucuronide conjugates by 45%, decreased lamotrigine AUC by 20%, and reduced lamotrigine trough concentrations by 25%. The Rapid Blast is a red liquid that contains 500 mg of acetaminophen per tablespoon 2. Administering charcoal dietary supplements at the same time as a routine acetaminophen dosage would be expected to interfere with the analgesic and antipyretic efficacy of acetaminophen. Max single dose: 15 mg/kg/dose or 750 mg/dose, whichever is less. You can now login to our website, manage your profile, receive email communications, and patient support materials. Ask a doctor or pharmacist before use if your child is taking the blood thinning drug warfarin. Zolmitriptan: (Minor) Zolmitriptan can delay the Tmax of acetaminophen by one hour. Tylenol Extra Strength products come in single doses of 500 milligrams (mg) per tablet, caplet, or powder pack. Monitor patients closely for signs and symptoms of methemoglobinemia if coadministration is necessary. The pharmacokinetic profile of IV acetaminophen in adults is dose proportional after administration of single doses of 500, 650, and 1,000 mg. Rectal RouteRectal absorption of acetaminophen is prolonged and highly variable compared to other routes of administration; reported bioavailability ranges from 6.5% to 98%. Norethindrone; Ethinyl Estradiol; Ferrous fumarate: (Moderate) Monitor for estrogen-related adverse effects during concomitant acetaminophen and ethinyl estradiol use. Cold, flu, allergy, and other commonly purchased over-the-counter medications often contain acetaminophen as one of the ingredients. For patients with a CrCl of 30 mL/minute or less, reduced dosing and prolonged intervals are recommended for IV dosing; however no quantitative recommendations are available. Do not exceed 48 consecutive hours at the maximum dose. Acetaminophen cessation led to serum transaminase normalization within 2 weeks. Bioavailability ranges from 85% to 98%. Also, the analgesic activity of acetaminophen may be reduced. Max single dose: 1,000 mg/dose. Bupivacaine; Meloxicam: (Moderate) Coadministration of bupivacaine with oxidizing agents, such as acetaminophen, may increase the risk of developing methemoglobinemia. Caution and close monitoring are advised if these drugs are administered together. Mercapturic acid and cysteine metabolites account for 5% to 12% of the urinary metabolites; less than 5% is excreted as unchanged drug. Ethinyl Estradiol; Norelgestromin: (Moderate) Monitor for estrogen-related adverse effects during concomitant acetaminophen and ethinyl estradiol use. Some experts recommend an initial load of 30 mg/kg PR. Caution and close monitoring are advised if these drugs are administered together. If methemoglobinemia occurs or is suspected, discontinue bupivacaine and any other oxidizing agents. This website is intended for U.S. healthcare professionals only. If you are not eligible for samples, you may still register to receive marketing and educational communications and access to information and resources from TYLENOL Professional. About 10 to 15% of the acetaminophen dose undergoes oxidative metabolism via cytochrome P450 isoenzymes CYP2E1, 3A4 and 1A2, which produces the hepatotoxic metabolite, N-acetyl-p-benzoquinonimine. Call Poison Help at 800-222-1222 or go to www.poison.org in the United States. Also, the analgesic activity of acetaminophen may be reduced. If aches, pains, or fever do not resolve in that time, talk to a doctor or other healthcare professional rather than continuing to take acetaminophen. Depending on the severity of symptoms, patients may respond to supportive care; more severe symptoms may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen. If a pet or animal is in pain or has a fever, veterinarians typically prescribe other medications more suitable for animals such as NSAIDs, gabapentin, or opioids. The mechanism of this interaction is not available (although it may be due to delayed gastric emptying from exenatide use) and the clinical impact has not been assessed. Reason: they are every 8-hour extended-release. [32569] [42289] Some studies have suggested an association between chronic use of acetaminophen and renal effects. Do not store for later use.- Discard vial after 6 hours- Do not freeze- Do not refrigerate- Store at controlled room temperature (between 68 and 77 degrees F)Pain & Fever :- Store between 68 to 77 degrees FPain and Fever :- Do not refrigerate- Store between 68 to 77 degrees FPAIN RELIEF :- Store between 68 to 77 degrees FPAIN RELIEF Extra Strength:- Store at 77 degrees F; excursions permitted to 59-86 degrees FPain Reliever:- Store between 68 to 77 degrees FPanadol:- Store at 77 degrees F; excursions permitted to 59-86 degrees FPediaCare Children's Fever Reducer/Pain Reliever:- Do not refrigerate- Store between 68 to 77 degrees FPediaCare Children's Smooth Metls Fever Reducer/Pain Reliever:- Avoid excessive humidity- Store at 77 degrees F; excursions permitted to 59-86 degrees FPediaCare Infant's Fever Reducer/Pain Reliever:- Do not refrigerate- Store between 68 to 77 degrees FPediaphen:- Store between 68 to 77 degrees FPHARBETOL:- Store between 68 to 77 degrees FPlus PHARMA:- Store at 77 degrees F; excursions permitted to 59-86 degrees FQ-Pap:- Do not refrigerate- Store between 68 to 77 degrees FQ-Pap Extra Strength:- Store at 77 degrees F; excursions permitted to 59-86 degrees FSilapap:- Do not refrigerate- Store between 68 to 77 degrees FTriaminic Fever Reducer and Pain Reliever:- Do not refrigerate- Store between 68 to 77 degrees FTriaminic Infant Fever Reducer and Pain Reliever:- Do not refrigerate- Store between 68 to 77 degrees FTylenol:- Store between 68 to 77 degrees FTylenol 8 Hour:- Avoid excessive heat (above 104 degrees F)- Store between 68 to 77 degrees FTylenol 8 Hour Arthritis Pain:- Avoid excessive heat (above 104 degrees F)- Store between 68 to 77 degrees FTylenol 8 Hour Muscle Aches & Pain:- Avoid excessive heat (above 104 degrees F)- Store between 68 to 77 degrees FTylenol Arthritis Pain:- Avoid excessive heat (above 104 degrees F)- Store between 68 to 77 degrees FTylenol Children's:- Do not refrigerate- Store between 68 to 77 degrees FTylenol Children's Pain+Fever:- Do not refrigerate- Store between 68 to 77 degrees FTylenol CrushableTablet:- Store at 77 degrees F; excursions permitted to 59-86 degrees FTylenol Extra Strength:- Store at 77 degrees F; excursions permitted to 59-86 degrees FTylenol Infants':- Do not refrigerate- Store between 68 to 77 degrees FTylenol Infants Pain + Fever:- Do not refrigerate- Store between 68 to 77 degrees FTylenol Junior Strength:- Store at 77 degrees F; excursions permitted to 59-86 degrees FTylenol Muscle Aches & Pain:- Avoid excessive heat (above 104 degrees F)- Store between 68 to 77 degrees FTylenol Pain + Fever:- Do not refrigerate- Store between 68 to 77 degrees FTylenol Regular Strength:- Store between 68 to 77 degrees FTylenol Sore Throat:- Store at controlled room temperature (between 68 and 77 degrees F)XS No Aspirin:- Store between 15 to 30 degrees C (59 - 86 degrees F)XS Pain Reliever:- Store at 77 degrees F; excursions permitted to 59-86 degrees F. Acetaminophen is contraindicated in patients with a known acetaminophen hypersensitivity or hypersensitivity to any of the excipients of the formulation to be used. Administration of acetaminophen should be limited or avoided altogether in patients with alcoholism or patients who consume alcohol regularly. 3,000 mg in 24 hours Brand Names. How Many 500 mg Tylenol Can I Take? In patients with chronic hepatic disease, acetaminophen can be used safely; use the smallest dose for the shortest duration necessary. Acetaminophen is a substrate of UDP-glucuronyltransferases. We have made some changes to our site and we need you to create a new password in order to login. In addition, cytochrome P450 activity is not increased and glutathione stores are not depleted in hepatically impaired patients taking therapeutic doses, therefore toxic metabolite formation and accumulation is not altered. The risk increased with an increasing cumulative acetaminophen lifetime dose. Tizanidine: (Minor) Tizanidine delays the time to attain peak concentrations of acetaminophen by about 16 minutes. Also, the analgesic activity of acetaminophen may be reduced. The average dose used during periods of regular acetaminophen use also correlated with risk, as those who took at least 1.4 grams/day during periods of regular use had an odds ratio for chronic renal failure of 5.3; duration of therapy was unrelated to risk. Do not give more than 4 doses in 24 hours. Competition for the metabolic pathway is thought to have caused a case of acetaminophen-related hepatotoxicity. For adults and adolescents 12 years or older, Tylenol Extra Strength can be used to reduce fever. Less than a 2-fold increase in the midazolam AUC is not considered clinically important. This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever. Monitor patients closely for signs and symptoms of methemoglobinemia if coadministration is necessary. Acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation. Do not exceed 1 g/dose or 4 g/day. Efficacy of IV acetaminophen for the treatment of acute pain has not been established in patients younger than 2 years. TYLENOL Dosage for Adults Safe Acetamenophen Dosing for Adults Share It is important to note that maximum daily doses and labeling instructions differ between Canada and the United States. 325 to 650 mg PO every 4 to 6 hours as needed. Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with . Looks like you have an existing account with us. Vd is approximately 1 L/kg in children and adults. Caution and close monitoring are advised if these drugs are administered together. Please check your email for a reset link to continue the reset process. and get free shipping at $35. If you are experiencing chronic pain and feel that you need more than 3000 mg of Tylenol in one day, talk to your doctor. Depending on the severity of symptoms, patients may respond to supportive care; more severe symptoms may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen. Butabarbital: (Minor) Chronic therapy with barbiturates can increase the metabolism and decrease the effectiveness of acetaminophen. The biggest cause of liver . For oral and rectal dosage forms (capsules, granules, powders, solution, suppositories, suspension, or tablets): Adults and teenagers650 to 1000 milligrams (mg) every 4 to 6 hours as needed. If, however, the fever rises above 103 or lasts for longer than three days, discontinue the use of Tylenol Extra Strength and talk to a healthcare provider. Competition for the metabolic pathway is thought to have caused a case of acetaminophen-related hepatotoxicity. Alternatively, 7.5 mg/kg/dose IV every 8 hours as needed has been suggested. 5 B. For acetaminophen doses greater than the maximum recommended daily dose, OBRA guidelines recommend a documented assessment reflecting periodic monitoring of liver function and an indication that the benefits of therapy outweigh the risks. Acetaminophen is administered orally, rectally, or intravenously. Use with caution in patients with hepatic dysfunction. Penicillin G Procaine: (Moderate) Coadministration of penicillin G procaine with oxidizing agents, such as acetaminophen, may increase the risk of developing methemoglobinemia. Ethinyl Estradiol; Norgestrel: (Moderate) Monitor for estrogen-related adverse effects during concomitant acetaminophen and ethinyl estradiol use. Do not take more than 6 caplets in 24 hours, unless directed by a doctor. Some experts recommend an initial load of 20 mg/kg PO. {* traditionalSignIn_password *}, {* traditionalSignIn_signInButton *} Concomitant acetaminophen ingestion may result in increases in the INR in a dose-related fashion. Lomitapide: (Moderate) Caution should be exercised when lomitapide is used with other medications known to have potential for hepatotoxicity, such as acetaminophen (> 4 g/day PO for >= 3 days/week). Advise patients to discontinue treatment and seek immediate medical attention with any signs or symptoms of methemoglobinemia. Alternatively, 7.5 mg/kg/dose IV every 8 hours as needed has been suggested. Remind them to always read and follow the product label and use ONLY 1 medicine containing the same active ingredient at a time. To avoid potential pharmacokinetic interactions that might alter effectiveness of acetaminophen, it may be advisable for patients to take acetaminophen at least one hour prior to lixisenatide subcutaneous injection. Taking more, especially 7,000 mg or more, can lead to a severe overdose problems. Depending on the severity of symptoms, patients may respond to supportive care; more severe symptoms may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen. The FDA-approved dose for fever in this age group is 12.5 mg/kg/dose IV every 6 hours as needed; Max daily dose: 50 mg/kg/day. 10 to 15 mg/kg/dose PO every 6 to 8 hours as needed. Consult specific product labeling for inactive ingredient content. . A single 1 g dose of acetaminophen does not alter the pharmacokinetics of zolmitriptan and its active metabolite. Intravenous acetaminophen requires dosage adjustment for those with a creatinine clearance (CrCl) of 30 mL/minute or less; do not administer any form of acetaminophen more frequently than every 8 hours in patients with a CrCl less than 10 mL/minute. Chewable tablets: May be swallowed whole or chewed. The P450 isoenzymes 1A2 and 3A4 appear to have a minor role in the metabolism of acetaminophen. Dapsone: (Moderate) Coadministration of dapsone with acetaminophen may increase the risk of developing methemoglobinemia. Acetaminophen AUC, Cmax, and Tmax were not significantly changed when acetaminophen was given 1 h before lixisenatide injection. Though the half-life of acetaminophen may be prolonged, repeated dosing does not result in drug or metabolite accumulation. Drugs.com warns that the maximum recommended amount of acetaminophen for adults is 1000 mg per dose and 4000 mg per day 2. Conflicting data exists on whether therapeutic doses of acetaminophen can cause hemolysis in G6PD deficient patients. document.write(new Date().getFullYear()) PDR, LLC. The suppository must be retained in rectum to ensure complete absorption. (Moderate) Coadministration of lidocaine with oxidizing agents, such as acetaminophen, may increase the risk of developing methemoglobinemia. If methemoglobinemia occurs or is suspected, discontinue penicillin G procaine and any other oxidizing agents. If methemoglobinemia occurs or is suspected, discontinue chloroprocaine and any other oxidizing agents. 10 to 15 mg/kg/dose PO every 12 hours as needed. Symptoms may include: skin reddening blisters rash Register Now. adult takes more than 4,000 mg of acetaminophen in 24 hours child takes more than 5 doses in 24 hours taken with other drugs containing acetaminophen adult has 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Severe hepatic dysfunction including fatalities were reported in patients taking rifampin with other hepatotoxic agents. Depending on the severity of symptoms, patients may respond to supportive care; more severe symptoms may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen. If methemoglobinemia occurs or is suspected, discontinue bupivacaine and any other oxidizing agents. Tylenol 8 HR, primarily intended for the relief of muscle aches or arthritis pain, contains a higher dose (650 mg) of acetaminophen in an extended-release format. if the user has ever had an allergic reaction to this product or any of its ingredients. Ritonavir: (Moderate) Concurrent administration of acetaminophen with ritonavir may result in elevated acetaminophen plasma concentrations and subsequent adverse events. Children 12 years and Adolescents: If methemoglobinemia occurs or is suspected, discontinue lidocaine and any other oxidizing agents. Acetaminophen does not inhibit PG synthesis in peripheral tissues, which is the reason for its lack of peripheral anti-inflammatory effects. Acetaminophen may induce glucuronidation pathways involved in lamotrigine metabolism. A loading dose of 20 mg/kg IV, then 10 mg/kg/dose IV every 12 hours as needed has been recommended. Max single dose: 1,000 mg/dose. As a symptom medication, any missed dose of Tylenol Extra Strength can be taken when remembered, provided symptoms are still present. High-dose rectal acetaminophen (25 to 45 mg/kg/dose) has been studied and recommended as an initial loading dose for pain management, as well as for the scheduled management of peri- and postoperative pain, in pediatric patients. Some experts recommend an initial load of 20 mg/kg PO. The elimination half-life of acetaminophen is 2 to 3 hours in healthy adult patients. Tylenol 500 mg is considered extra strength.. By submitting your information, you agree to the Financial Incentive Notice. The AAP and other experts regard acetaminophen as a maternal medicine that is usually compatible with breast-feeding. Depending on the severity of symptoms, patients may respond to supportive care; more severe symptoms may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen. To avoid potential pharmacokinetic interactions that might alter effectiveness of acetaminophen, it may be advisable for patients to take acetaminophen at least one hour prior to lixisenatide subcutaneous injection. None of the infants with malformations were exposed during the first trimester, but all of the spontaneous abortions were subsequent to first trimester exposure. Lamivudine, 3TC; Zidovudine, ZDV: (Minor) Both acetaminophen and zidovudine, ZDV undergo glucuronidation. INFANTS' TYLENOL CONCENTRATED DROPS (80 MG/1 ML) CHILDREN'S TYLENOL SUSPENSION LIQUID (160 MG/5 ML) CHILDREN'S TYLENOL CHEWABLES . The combination of isoniazid and acetaminophen has caused severe hepatotoxicity in at least one patient; studies in rats have demonstrated that pre-treatment with isoniazid potentiates acetaminophen hepatotoxicity. Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache, backache, minor pain of arthritis, toothache, muscular aches, and premenstrual and menstrual cramps also temporarily reduces fever Desogestrel; Ethinyl Estradiol: (Moderate) Monitor for estrogen-related adverse effects during concomitant acetaminophen and ethinyl estradiol use. Acetaminophen Tylenol oz Medicine, Infants' , & Tylenol mg Extra ct Caplets Pain 24 Reliever with 500 Strength , 8 Arthritis Pain, Tablets for 24 with Joint Acetaminophen Hour , Pain, ct Hour 8 with Tylenol Pain Joint 24 Tablets , 500 and Pain Caplets Extra Acetaminophen Reducer,. Severe liver damage may occur if you take. Medically reviewed by Megan Huang, Pharm.D. Also, the analgesic activity of acetaminophen may be reduced. However, large doses may cause unwanted side effects or liver damage. When the body breaks down acetaminophen, some of it is converted into poison. What Are Serious Side Effects of Tylenol 500 mg? Also temporarily reduces fever. Caution must be used during the preparation and administration of IV acetaminophen, as well as the measurement of oral liquid dosage forms to minimize the risk of dosing errors that can result in accidental overdose. Acetaminophen is used to help: Reduce aches, pain, sore throat, and fever in children with a cold or the flu Relieve pain from a headache or toothache Proper Dosing of Liquids and Tablets Children's acetaminophen can be taken as liquid or chewable tablet. Children should not take acetaminophen daily for longer than five days. Therefore, in general, use of acetaminophen is preferable to ibuprofen if the patient has stomach upset or is not drinking well. 1,000 mg/dose PO/PR/IV or 4,000 mg/day PO/PR/IV for most formulations; some OTC formulations have lower max doses, see individual products. It is important to note that doses effective for acute pain relief may not be effective in chronic pain states, which require higher daily doses. Prilocaine: (Moderate) Coadministration of prilocaine with oxidizing agents, such as acetaminophen, may increase the risk of developing methemoglobinemia. See Additional Information. ChildrenDose is based on weight or age. Indications: Treatment of fever and pain. Your personal information will be used to fulfill your request for samples and/or patient education materials. In clinical trials, there was no difference in analgesic effect, measured by the reduced need for additional opioid treatment for pain control, in patients younger than 2 years receiving opioid plus acetaminophen vs. opioid plus placebo. Acetaminophen is widely distributed throughout most body tissues except fat; low protein binding and molecular weight allow blood-brain barrier penetration. Acetaminophen AUC, Cmax, and Tmax were not significantly changed when acetaminophen was given 1 h before exenatide injection. Max single dose: 20 mg/kg/dose. Take 2 caplets every 6 hours while symptoms last. Most healthcare professionals who register are eligible for samples. Acetaminophen may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation. Lanthanum Carbonate: (Minor) The manufacturer recommends that oral compounds known to interact with antacids, such as acetaminophen, should not be taken within 2 hours of dosing with lanthanum carbonate. Max single dose: 1,000 mg/dose. The mechanism of this interaction is not available (although it may be due to delayed gastric emptying) and the clinical impact has not been assessed. Carefully follow the label instructions for the maximum dose per day. High-dose rectal acetaminophen (25 to 45 mg/kg/dose) has been studied and recommended as an initial loading dose for pain management, as well as for the scheduled management of peri- and postoperative pain, in pediatric patients. Max daily dose: 75 mg/kg/day. It may be advisable for patients to avoid acetaminophen while taking metyrapone. Monitor patients closely for signs and symptoms of methemoglobinemia if coadministration is necessary. Chronic acetaminophen therapy should be avoided in patients receiving imatinib. Charcoal is mostly used in the setting of acetaminophen overdose; however, patients should never try to treat an acetaminophen overdose with charcoal dietary supplements. In addition, the risk of hepatotoxicity from acetaminophen may be increased with the chronic dosing of acetaminophen along with phenytoin. During acute overdoses, barbiturates can enhance the formation of toxic acetaminophen metabolites. Some experts recommend an initial load of 20 mg/kg PO. 12.5 mg/kg/dose IV every 6 hours as needed. A loading dose up to 20 mg/kg IV and maintenance doses up to 15 mg/kg IV (Max daily dose: 60 mg/kg/day IV) have been used off-label.0 to 9 days: 20 mg/kg PO load and 15 mg/kg/dose PO maintenance dose (Max daily dose: 60 mg/kg/day PO); 30 mg/kg PR load and 20 mg/kg/dose PR maintenance dose (Max daily dose: 60 mg/kg/day PR); 12.5 mg/kg/dose IV (Max daily dose: 50 mg/kg/day IV). Competition for the metabolic pathway is thought to have caused a case of acetaminophen-related hepatotoxicity. Allergy alert: Acetaminophen may cause severe skin reactions. Acute or chronic alcohol use increases acetaminophen-induced hepatotoxicity by inducing CYP2E1 leading to increased formation of the hepatotoxic metabolite of acetaminophen. Warfarin: (Minor) Although acetaminophen is routinely considered safer than aspirin and agent of choice when a mild analgesic/antipyretic is necessary for a patient receiving therapy with warfarin, acetaminophen has also been shown to augment the hypoprothrombinemic response to warfarin. Specifically, ensure that:the dose in milligrams (mg) and milliliters (mL) is not confusedweight-based dosing is used for patients weighing less than 50 kginfusion pumps are properly programmedthe total daily acetaminophen dose from all sources does not exceed recommended daily maximum limits, Intermittent IV Infusion PreparationNo further dilution of acetaminophen injectable solution is required.Do not add other medications to the vial or infusion device.For doses less than 1,000 mg, the appropriate dose must be withdrawn from the container using aseptic technique and placed in a separate empty, sterile container (e.g., glass bottle, plastic intravenous container, or syringe) prior to administration.For patients (weighing 50 kg or more) requiring a 1,000 mg dose, administer the dose by inserting an intravenous set directly in the container; use a vented set for vials and a non-vented set for bags.Storage: Acetaminophen containers are preservative free. 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