Long-term use of Voltaren gel may increase your risk of heart attack or stroke. Monitor Closely (1)acyclovir and teicoplanin both increase nephrotoxicity and/or ototoxicity. fluoxetine and cocaine topical both increase serotonin levels. Monitor for antidepressant response. fluoxetine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Increased risk of upper GI bleeding. Caution is advised when administering diclofenac to patients with mild to moderate hepatic impairment (see section 4.4 Special warnings and precautions for use). While Voltaren can help with some joint pain related to arthritis, the gel has not been shown to help with pain from: Talk with your healthcare provider before using Voltaren gel to be sure it's right for you. Some conditions may become worse when the drug is abruptly stopped. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine will increase the level or effect of morphine by affecting hepatic enzyme CYP2D6 metabolism. acyclovir will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. fluoxetine decreases effects of losartan by decreasing metabolism. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)fluoxetine, mefenamic acid. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including other SSRIs such as citalopram/paroxetine, SNRIs such as duloxetine/venlafaxine), tryptophan, among others. h/mL and 25.24 (12.95) ng/mL, respectively, at steady state on Day 8. WebNaproxen (Naprosyn, Anaprox DS) is an inexpensive drug used to reduce swelling and treat pain.It is also used for painful joint and muscular problems such as arthritis, tendinitis, bursitis, and gout.It is slightly more popular than comparable drugs. View the formulary and any restrictions for each plan. fluoxetine will increase the level or effect of ibuprofen IV by affecting hepatic enzyme CYP2C9/10 metabolism. The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses including diclofenac and in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Modify Therapy/Monitor Closely. Use Caution/Monitor. fluoxetine, metoclopramide intranasal. Manage and view all your plans together even plans in different states. Fish Oil for Arthritis and Joint Pain: Can It Help? National Library of Medicine. Get medical help right away if any of these very serious side effects occur: extreme tiredness, slow/fast/irregular heartbeat, easy bruising/bleeding, new fever, bloody/dark urine, severe stomach/abdominal pain, yellowing eyes/skin, sudden vision changes, loss of consciousness, seizures.A very serious allergic reaction to this drug is rare. acyclovir and amphotericin B deoxycholate both increase nephrotoxicity and/or ototoxicity. If diclofenac is used by a woman attempting to conceive, or during the first and second trimester of pregnancy, the dose should be kept as low and duration of treatment as short as possible. Use Caution/Monitor. Adults can take a dose of OTC ibuprofen every 4 to 6 hours. ECG should be monitored closely. Monitor Closely (1)alpelisib will decrease the level or effect of fluoxetine by affecting hepatic enzyme CYP2C9/10 metabolism. If also administered with a strong/moderate CYP3A4 inhibitor, administer a quarter of brexpiprazole dose. Symptoms of an overdose of this drug can include: If you think youve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. Diclofenac Sodium 50 mg tablets are not suitable for children. Step 6: Replace the cap on the bottle and store in an upright position. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. 2015;29(3):151-7. doi:10.1097/HNP.0000000000000085. You should not use Flaxseed oil can be added to smoothies, used in salad dressings, or drizzled on vegetables after cooking. Use Caution/Monitor. Increased risk of upper GI bleeding. Increased risk of upper GI bleeding. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. SIDE EFFECTS: See also Warning section.Nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning may occur. fluoxetine and indapamide both increase QTc interval. For people with ulcer or digestive bleeding: If youve had an ulcer or bleeding from your digestive system, ask your doctor before using diclofenac. Yes and no. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. clozapine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. SSRIs inhib. erythromycin stearate and fluoxetine both increase QTc interval. Benefits of Fish Oil for Heart Disease Prevention, 6 Ways to Shrink an Ovarian Cyst Without Surgery, 6 Best Herbs and Supplements for High Blood Pressure, Study: Fish Oil Supplement May Reduce COVID Severity, What to Know About Flaxseed Oil for Dry Eyes. Use Caution/Monitor. Avoid or Use Alternate Drug. Diclofenac enters the synovial fluid, where maximum concentrations are measured 2-4 hours after the peak plasma values have been attained. Avoid or Use Alternate Drug. serotonin uptake by platelets. Modify Therapy/Monitor Closely. Increased risk of upper GI bleeding. Monitor Closely (2)fluoxetine will increase the level or effect of diazepam intranasal by affecting hepatic enzyme CYP2C19 metabolism. Dont use this drug again if youve ever had an allergic reaction to it. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. Increased risk of upper GI bleeding. Panobinostat is known to significantly prolong QT interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). US residents can call their local poison control center at 1-800-222-1222. Modify Therapy/Monitor Closely. Diclofenac (Solaraze, Voltaren) topical gel is a prescription medication used to treat osteoarthritis pain and actinic keratoses. Modify Therapy/Monitor Closely.Minor (1)fluoxetine, zolmitriptan. It is not known whether diffusion into the joint plays a role in the effectiveness of diclofenac. Either increases toxicity of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Minor/Significance Unknown. Keep it in your carry-on bag. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug.fluoxetine and amitriptyline both increase serotonin levels. Do not apply external heat and/or occlusive dressings to treated knees. Monitor Closely (2)fluoxetine and dexfenfluramine both increase serotonin levels. Use Caution/Monitor. The use of Diclofenac may impair female fertility and is not recommended in women attempting to conceive. Contraindicated. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias. Avoid or Use Alternate Drug. Minor/Significance Unknown. Other drugs may interact with losartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Modify Therapy/Monitor Closely. WebAnswer your medical questions on prescription drugs, vitamins and Over the Counter medications. Serious - Use Alternative (1)fluoxetine and sotalol both increase QTc interval. etodolac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Other (see comment). fluoxetine, tolmetin. Minor (1)bumetanide, fluoxetine. fluoxetine and sotalol both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)fluoxetine and maprotiline both increase serotonin levels. Minor/Significance Unknown. Monitor when coadministered with weak CYP3A4 inhibitors . Monitor Closely (1)vorinostat and fluoxetine both increase QTc interval. hydrochlorothiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Diclofenac Topical (arthritis pain). In some cases, they may not be available in every strength or form as a brand-name drug. U.S. Food & Drug Administration. Monitor Closely (1)fluoxetine and umeclidinium bromide/vilanterol inhaled both increase QTc interval. Either increases effects of the other by serotonin levels. fluoxetine, sulindac. Monitor Closely (1)gemifloxacin and fluoxetine both increase QTc interval. Use Caution/Monitor.trifluoperazine and fluoxetine both increase QTc interval. Properly discard this product when it is expired or no longer needed. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. fluoxetine and lapatinib both increase QTc interval. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. During concomitant use of PENNSAID and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. Monitor Closely (1)valerian and fluoxetine both increase sedation. Minor/Significance Unknown. Do not use it later for another infection unless your doctor tells you to. Flaxseed oil is high in omega-3 fatty acids and other healthful compounds shown to have a variety of health benefits. Use Caution/Monitor. Increased risk of upper GI bleeding. Either increases toxicity of the other by serotonin levels. first sign of any skin rash (no matter how mild). Use Caution/Monitor. Patients with defects of haemostasis, bleeding diathesis or haematological abnormalities should be carefully monitored. lumacaftor/ivacaftor, fluoxetine. They cant harm your medication. Monitor Closely (2)fluoxetine will increase the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)zolmitriptan and fluoxetine both increase serotonin levels. fluoxetine, insulin inhaled. fluoxetine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. A: Generally acceptable. Consider lofexidine dose reduction.fluoxetine and lofexidine both increase QTc interval. fluoxetine will increase the level or effect of fesoterodine by affecting hepatic enzyme CYP2D6 metabolism. Increased risk of upper GI bleeding. Using it again could be fatal (cause death). Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Wait until the treated area is dry before applying sunscreen, insect repellant, lotion, moisturizer, cosmetics, or other topical medication to the same knee you have just treated with PENNSAID. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)imipramine and fluoxetine both increase QTc interval. sulindac will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. Your doctor may increase your dose as needed. By Carol Eustice morphine, fluoxetine. ceritinib and fluoxetine both increase QTc interval. Caution is advised when administering diclofenac to patients with mild to moderate renal impairment (see section 4.4 Special warnings and precautions for use). If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.A very serious allergic reaction to this drug is rare. Diclofenac topical gel may cause drowsiness. chloroquine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)anagrelide and fluoxetine both increase QTc interval. Minor (1)acyclovir will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Do not double the dose to catch up. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. fluoxetine and panobinostat both increase QTc interval. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular system. Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. If coadministered with strong CYP2D6 inhibitors, initiate pitolisant at 8.9 mg/day and increase after 7 days to maximum of 17.8 mg/day. erythromycin base and fluoxetine both increase QTc interval. Monitor Closely (1)naratriptan and fluoxetine both increase serotonin levels. Avoid or Use Alternate Drug. fluoxetine increases toxicity of cilostazol by affecting hepatic enzyme CYP2C19 metabolism. Minor (1)acyclovir will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Increased risk of upper GI bleeding. Monitor Closely (1)fluoxetine, aspirin rectal. Coadministration with drugs that lower seizure threshold may increase this risk. Serious - Use Alternative (1)fluoxetine and ibutilide both increase QTc interval. Use Caution/Monitor. The total dosage of diclofenac gel shouldnt be more than 32 gm per day, over all affected joints. Either increases effects of the other by serotonin levels. Use Caution/Monitor. take a shower or a bath for at least30 minutes after you put PENNSAID on your knee(s). Avoid or Use Alternate Drug. Minor/Significance Unknown. fluoxetine will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. goserelin increases toxicity of fluoxetine by QTc interval. This article discusses the evidence for these and other possible health benefits, along with side effects to be aware of and precautions to take when adding flaxseed oil to your diet. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Avoid or Use Alternate Drug. Minor/Significance Unknown. It may harm an unborn baby. Modify Therapy/Monitor Closely. quetiapine, fluoxetine. Minor/Significance Unknown. Serious - Use Alternative (1)fluoxetine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use only the number of milligrams per dose that is fluoxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. A category C drug means that means that studies have shown that the drug can be a risk to the offspring of lab animals. Either increases toxicity of the other by serotonin levels. Mechanism: unknown. fluoxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. fluoxetine will increase the level or effect of loratadine by affecting hepatic enzyme CYP2D6 metabolism. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Fluoxetine can stay in your body for many weeks after your last dose and may interact with many other medications. Monitor Closely (1)fluoxetine and salmeterol both increase QTc interval. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs. Serious - Use Alternative (1)arsenic trioxide and fluoxetine both increase QTc interval. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Monitor Closely (1)droperidol and fluoxetine both increase QTc interval. Monitor Closely (2)fenfluramine, fluoxetine. Therefore, diclofenac should not be administered during breast feeding in order to avoid undesirable effects in the infant (see section 5.2). Avoid or Use Alternate Drug. Minor/Significance Unknown. Serious - Use Alternative (1)oxaliplatin and fluoxetine both increase QTc interval. dronedarone and fluoxetine both increase QTc interval. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Serious - Use Alternative (2)fluphenazine and fluoxetine both increase QTc interval. Effect of flaxseed intervention on inflammatory marker C-reactive protein: A systematic review and meta-analysis of randomized controlled trials. Table 4: Change in Treatment Outcomes after 4 Weeks of Treatment with PENNSAID, PENNSAID WebDrugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Too much of the drug in your body can be dangerous. fluoxetine will increase the level or effect of flurbiprofen by affecting hepatic enzyme CYP2C9/10 metabolism. This could result in dangerous side effects. Serious - Use Alternative (1)buprenorphine transdermal and fluoxetine both increase QTc interval. Monitor Closely (1)fluoxetine and terbutaline both increase QTc interval. Modify Therapy/Monitor Closely. fluoxetine and trimipramine both increase serotonin levels. Use Caution/Monitor. Serious - Use Alternative (1)fluoxetine will increase the level or effect of methamphetamine by affecting hepatic enzyme CYP2D6 metabolism. fluoxetine will increase the level or effect of tolterodine by affecting hepatic enzyme CYP2D6 metabolism. Increased risk of upper GI bleeding. fluoxetine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fluoxetine and formoterol both increase QTc interval. artemether and fluoxetine both increase QTc interval. Dosage Forms and Strengths. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)lefamulin and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. ritonavir will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Report any new or worsening symptoms to your SSRIs inhib. Children 6 years of age and olderDose is based on body weight and must be determined by your doctor. WebHydroxylated metabolite, Doxazosin; Route of elimination. Monitor Closely (1)fluoxetine and olodaterol inhaled both increase QTc interval. Mechanism: pharmacodynamic synergism. Assess need to reduce dose of CYP2D6-metabolized drug. Use Caution/Monitor. 2022 Dotdash Media, Inc. All rights reserved. Minor/Significance Unknown. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Monitor Closely (1)fluoxetine increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. This Instructions for Use has been approved by the U.S. Food and Drug Administration. Increased risk of upper GI bleeding. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)efavirenz and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Monitor Closely (2)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. fedratinib will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. fluoxetine will increase the level or effect of voriconazole by affecting hepatic enzyme CYP2C19 metabolism. ALA is converted to EPA and DHA in the body, while flaxseed naturally contains omega-3 fatty acids., Flaxseed oil has laxative properties. Monitor Closely (1)sumatriptan intranasal and fluoxetine both increase serotonin levels. if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAIDs. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain. Modify Therapy/Monitor Closely. Increased risk of upper GI bleeding. Other NSAIDS including cyclo-oxygenase-2 selective inhibitors and corticosteroids: Co-administration of diclofenac and other systemic NSAIDs or corticosteroids may increase the risk of gastrointestinal bleeding or ulceration. How Pennsaid Topical Solution Helps Knee Osteoarthritis, 9 Ways to Reduce Your Risk of Bleeding Ulcers From NSAID Use, Voltaren (Diclofenac) vs. Advil (Ibuprofen). Monitor Closely (1)fluoxetine will increase the level or effect of bosentan by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. quinidine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. flurbiprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. fluoxetine and fostemsavir both increase QTc interval. Voltaren - diclofenac sodium gel. Previous. Some may be better suited for you than others. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. The FDA has also approved a 3% strength Voltaren gel that can be bought over-the-counter (OTC) and used by people with actinic keratosisa condition that causes rough, scaly skin patches that can turn into cancer. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. acyclovir, elvitegravir/cobicistat/emtricitabine/tenofovir DF. sunitinib and fluoxetine both increase QTc interval. To view the changes to a medicine you must sign up and log in. fluoxetine will increase the level or effect of pitolisant by affecting hepatic enzyme CYP2D6 metabolism. She providesmedical nutrition therapy at Lenox Hill Hospital and is based in New York, New York. Modify Therapy/Monitor Closely. Avoid alcoholic beverages. Effect of L. usitatissimum (flaxseed/linseed) fixed oil against distinct phases of inflammation. Flaxseed oil is used for a range of health concerns, including reducing inflammation and preventing cancer. Monitor Closely (2)fluoxetine will increase the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)clomipramine and fluoxetine both increase QTc interval. Monitor Closely (2)fluoxetine will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Both drugs decrease blood glucose. Be especially sure to avoid using diclofenac at 30 weeks of pregnancy and later. Minor (1)fluoxetine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by serotonin levels. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. Modify Therapy/Monitor Closely. Minor/Significance Unknown. fluoxetine will increase the level or effect of oliceridine by affecting hepatic enzyme CYP2D6 metabolism. arformoterol and fluoxetine both increase QTc interval. Either increases toxicity of the other by Mechanism: unknown. Monitor Closely (1)fluoxetine increases effects of insulin glulisine by unspecified interaction mechanism. Please confirm that you would like to log out of Medscape. The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice.AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more Minor (1)panax ginseng increases effects of fluoxetine by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Avoid with drugs known to prolong QT interval. eribulin and fluoxetine both increase QTc interval. Risk of neurotoxicity. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. As with other nonsteroidal anti-inflammatory agents, diclofenac in high dose can reversibly inhibit platelet aggregation. Monitor Closely (1)fluoxetine, fenoprofen. Adults and children under 12 years of age: aspirin, acetaminophen, ibuprofen, tramadol, cyclobenzaprine, Tylenol, Paracetamol, diclofenac, naproxen, oxycodone. Minor (1)metolazone will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)fluoxetine increases effects of glimepiride by unspecified interaction mechanism. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Monitor Closely (1)remifentanil, fluoxetine. buprenorphine and fluoxetine both increase QTc interval. Use Caution/Monitor.fluoxetine, meloxicam. Increases risk of torsades de pointes. Risk of neurotoxicity. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions. Carol Eustice is a writer covering arthritis and chronic illness, who herself has been diagnosed with both rheumatoid arthritis and osteoarthritis. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Protect your treated knee from sunlight. Either increases toxicity of the other by pharmacodynamic synergism. Webdiclofenac. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. encorafenib and fluoxetine both increase QTc interval. 2012;58(2):490-5. doi:10.1016/j.appet.2011.12.024, Cetisli NE, Saruhan A, Kivcak B. Minor (1)bendroflumethiazide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. On a blood test, your levels might be higher than normal even before you have symptoms. Modify Therapy/Monitor Closely. Use Caution/Monitor. Stomach ulcer or stomach bleeding. Compare formulary status to other drugs in the same class. Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. Monitor Closely (1)promethazine and fluoxetine both increase QTc interval. granisetron, fluoxetine. Either increases toxicity of the other by serotonin levels. Linezolid may increase serotonin as a result of MAO-A inhibition. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Although no drug interactions studies have been performed, antiherpetic viral agents may interfere with the effectiveness of talimogene laherparepvec. Increased risk of upper GI bleeding. Use Caution/Monitor. SSRIs inhib. Discontinue buprenorphine if serotonin syndrome is suspected. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. She shares advice on living well with chronic disease. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Minor/Significance Unknown. If you notice any of these symptoms in your newborn, tell the doctor promptly.Since untreated mental/mood problems (such as depression, post traumatic stress disorder) can be a serious condition, do not stop taking this medication unless directed by your doctor. (ii) acute musculo-skeletal disorders such as periarthritis (for example frozen shoulder), tendinitis, tenosynovitis, bursitis. Monitor Closely (2)lasmiditan, fluoxetine. fluoxetine, ibuprofen. Monitor Closely (1)fluoxetine and mirtazapine both increase serotonin levels. The absolute risk for cardiovascular malformation was increased from less than 1%, up to approximately 1.5 %. Avoid or Use Alternate Drug. Combination therapy with protective agents (e.g. Use Caution/Monitor. Avoid or Use Alternate Drug.fluoxetine and dextromethorphan both increase serotonin levels. SSRIs inhib. Avoid or Use Alternate Drug. 2014;51(9):1633-53. doi:10.1007/s13197-013-1247-9, Ren GY, Chen CY, Chen GC, et al. Avoid or Use Alternate Drug. Data from epidemiological studies suggest an increased risk of miscarriage and of cardiac malformation and gastroschisis after use of a prostaglandin synthesis inhibitor in early pregnancy. You and your provider can talk about the risks and benefits and decide if it would be a good idea for you to use Voltaren. If your doctor wants you to use it for a longer time, your doctor should check your liver function, kidney function, and blood pressure periodically. The rest of the dose is eliminated as metabolites through the bile in the faeces. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. Minor (1)maraviroc will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. One animal study published in 2013 found flaxseed oil offered impressive inflammation-lowering benefits. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding. Use Caution/Monitor. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Modify Therapy/Monitor Closely.Minor (1)nilotinib will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants. How to tell if the drug is working: Your symptoms should improve. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: dizziness, drowsiness, signs of kidney problems (such as a change in the amount of urine, unusual back/side pain), mental/mood changes (such as agitation, confusion, hallucinations), shaky/unsteady movement, trouble speaking.This medication may rarely cause a life-threatening disorder that affects the blood cells, kidneys, and other parts of the body. Increases risk of torsades de pointes. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Either increases toxicity of the other by pharmacodynamic synergism. Comment: Defibrotide may enhance effects of platelet inhibitors. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. This website also contains material copyrighted by 3rd parties. fluoxetine will increase the level or effect of lofepramine by affecting hepatic enzyme CYP2D6 metabolism. difelikefalin and fluoxetine both increase sedation. Use Caution/Monitor. acyclovir and ioversol both increase nephrotoxicity and/or ototoxicity. ECG monitoring is recommended, along with drugs that may prolong the QT interval. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor patients for symptoms of serotonin syndrome if SSRIs are coadministered with safinamide. Minor/Significance Unknown. This helps to reduce inflammation and pain. Read the Medication Guide that comes with PENNSAID first. Minor/Significance Unknown. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Monitor Closely (1)fluoxetine will increase the level or effect of fluvastatin by affecting hepatic enzyme CYP2C9/10 metabolism. ECG monitoring is recommended. Minor/Significance Unknown. tolfenamic acid will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely.Serious - Use Alternative (3)fluoxetine and imipramine both increase serotonin levels. fluoxetine, meclofenamate. Modify Therapy/Monitor Closely. Use Caution/Monitor. serotonin uptake by platelets. SIDE EFFECTS: Nausea, diarrhea, headache, or vomiting may occur. Drink plenty of fluids while taking this medication unless your doctor directs you otherwise.If you are using the liquid form of this medication, shake the bottle well before each dose. Avoid or Use Alternate Drug. thiothixene and fluoxetine both increase QTc interval. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely.Serious - Use Alternative (2)escitalopram and fluoxetine both increase serotonin levels. Use Caution/Monitor. Serious - Use Alternative (1)fluoxetine and glasdegib both increase QTc interval. albuterol and fluoxetine both increase QTc interval. Monitor Closely (1)fluoxetine, buprenorphine subdermal implant. Minor/Significance Unknown. fluoxetine, buprenorphine, long-acting injection. Diclofenac may interact with other medications, Important considerations for using diclofenac, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f64b68a5-d6d2-4e92-87e7-90af04c1f9db, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89a7bfbd-051f-4d87-a642-96b0df81b8e2, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=60045fc6-f0d9-4f67-ba91-c3b317596437, Stages of Osteoarthritis (OA) of the Knee, Everything You Need to Know About Sexually Transmitted Infections (STIs), Every Sunscreen Question You Have, Answered. Minor/Significance Unknown. fluoxetine will increase the level or effect of alosetron by affecting hepatic enzyme CYP2C9/10 metabolism. Increased risk of upper GI bleeding. Use Caution/Monitor. Monitor Closely (1)ciprofloxacin and fluoxetine both increase QTc interval. Either increases toxicity of the other by serotonin levels. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Patients with renal impairment: In patients suffering from renal impairment, no accumulation of the unchanged active substance can be inferred from the single-dose kinetics when applying the usual dosage schedule. serotonin uptake by platelets. Monitor Closely (1)lamotrigine increases toxicity of fluoxetine by unspecified interaction mechanism. Minor/Significance Unknown. fluoxetine and tapentadol both increase serotonin levels. All material on this website is protected by copyright, Copyright 1994-2022 by WebMD LLC. You will also learn about the side effects of Voltaren, as well as which conditions it is not approved to treat. Javor S, Cozzani E, Parodi A. Topical treatment of actinic keratosis with 3.0% diclofenac in 2.5% hyaluronan gel: review of the literature about the cumulative evidence of its efficacy and safety. Minor/Significance Unknown. This may lead to dangerous effects for the child. fluoxetine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. One 2015 study of 140 menopausal women using flaxseed oil supplements showed a decrease in hot flashes and an increase in quality of life.. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. The following interactions include those observed with diclofenac gastro-resistant tablets and/or other pharmaceutical forms of diclofenac. Use Caution/Monitor. Risk of long QT syndrome. Use Caution/Monitor. Quinolone antimicrobials: Convulsions may occur due to an interaction between quinolones and NSAIDs. Modify Therapy/Monitor Closely. Use the lowest effective dosage for the shortest possible duration. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)fluoxetine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug. Minor/Significance Unknown. Avoid or Use Alternate Drug. Lomitapide dose should not exceed 30 mg/day. For the full list of excipients, see section 6.1. Modify Therapy/Monitor Closely. Use Caution/Monitor. Using diclofenac with certain blood pressure medications may also increase your risk of kidney damage. Avoid or Use Alternate Drug. Serious - Use Alternative (1)fluoxetine will increase the level or effect of timolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Risk of hypoglycemia. If you log out, you will be required to enter your username and password the next time you visit. You should also know that long-term NSAID use can lead to serious kidney problems like renal papillary necrosis, a condition where parts of the kidney die. Either increases effects of the other by pharmacodynamic synergism. SSRIs affect platelet activation; coadministration of SSRIs with clopidogrel may increase the risk of bleeding.Serious - Use Alternative (1)fluoxetine decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. ibrutinib will increase the level or effect of fluoxetine by anticoagulation. Avoid or Use Alternate Drug. Diclofenac is a prescription drug. Use Caution/Monitor. For seniors: Seniors are at higher risk for stomach problems, bleeding, water retention, and other side effects from diclofenac. Avoid or Use Alternate Drug. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically. QTc prolongation reported with higher than recommended doses of fostemsavir. Diclofenac topical gel is available as the brand-name drugs Solaraze and Voltaren. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.midazolam intranasal, fluoxetine. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)acyclovir will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)fluvoxamine and fluoxetine both increase serotonin levels. Modify Therapy/Monitor Closely.Minor (1)fluoxetine, rizatriptan. panax ginseng increases effects of fluoxetine by pharmacodynamic synergism. This can be a sign of serious liver problems that could lead to the need for a liver transplant or even be fatal if not treated. A: Generally acceptable. Monitor Closely (1)fluoxetine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)chlorthalidone will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by Other (see comment). If it is near the time of the next dose, skip the missed dose. The tablets are presented in aluminium/PVC or PVDC-coated-PVC blisters, strips of which are contained within a printed cardboard carton. Thank you, {{form.email}}, for signing up. Recommendations. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Avoid or Use Alternate Drug. sorafenib and fluoxetine both increase QTc interval. Increased risk of upper GI bleeding. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen , celecoxib , diclofenac, indomethacin, meloxicam, and others. Avoid taking selinexor with other medications that may cause dizziness or confusion. Monitor Closely (2)fluoxetine will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. Risk of weakness, dyspnea, chest pain. Diclofenac sodium is the active ingredient in Voltaren gel. Use Caution/Monitor. Use Caution/Monitor. Avoid concurrent use of bacitracin with other nephrotoxic drugs. Monitor Closely (1)eletriptan and fluoxetine both increase serotonin levels. Avoid or Use Alternate Drug.fluoxetine and doxepin both increase serotonin levels. Concomitant use of insulin and fluoxetine may require insulin dosage adjustment and increased glucose monitoring. Avoid or Use Alternate Drug. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Either increases toxicity of the other by pharmacodynamic synergism. serotonin uptake by platelets. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)fluoxetine, warfarin. Use Caution/Monitor. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. fluoxetine and levomilnacipran both increase serotonin levels. If you stop taking the drug or dont take it at all: If you stop using diclofenac and still have swelling and pain, you could have joint or muscle damage that doesnt heal. fluvoxamine and fluoxetine both increase serotonin levels. Modify Therapy/Monitor Closely. Minor/Significance Unknown. both of which are similar to the values observed in adults. Use Caution/Monitor. SSRIs may inhibit platelet aggregation, thus increase bleeding risk when coadministered with anticoagulants. Use Caution/Monitor. SSRIs inhib. pentoxifylline increases toxicity of fluoxetine by anticoagulation. fluoxetine and voriconazole both increase QTc interval. 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